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In this Article we use a set of 125 experimentally characterized glucagon and GLP-1 peptide analogues to train models that capture the relationship between peptide sequence and agonism or receptor activation at both the GCGR and GLP-1R
The oxime bond is the result of the condensation reaction between a ketone or aldehyde and an aminooxy moiety to form a ketoxime or aldoxime, respectively
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