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The cardiovascular outcomes trials that enrolled tens of thousands of patients with type 2 diabetesincluding LEADER (liraglutide), SUSTAIN-6 (semaglutide), REWIND (dulaglutide), and EXSCEL (exenatide ER)found no significant increase in overall cancer incidence compared to placebo over follow-up periods ranging from approximately two to five years

Continue protocol through initial period allowing adequate exposure time

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Funding assistance was provided by the National Research Foundation, South Africa, grant number: 98862 to SBMC and the University of Cape Town

A new Nature Portfolio review maps how amino acids, fatty acids, incretins, pharmaceuticals, food additives, environmental chemicals, stress, exercise and biological sex can shape -cell function and insulin release