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Trial Metric Retatrutide 12mg (TRIUMPH-4) Semaglutide 2.4mg (STEP 1) Mean Weight Loss 28.7% at 68 weeks 14.9% at 68 weeks Mechanism Triple agonist (GLP-1/GIP/GCGR) Single agonist (GLP-1) FDA Status Phase 3 (investigational) Approved (Wegovy) Dosing Weekly subcutaneous Weekly subcutaneous Common Adverse Events GI (nausea, vomiting, diarrhea), dysesthesia GI (nausea, vomiting, diarrhea) Important caveat: These results come from different trial populations and study designs

The researchers reported that high-fat meals did not impact the pharmacokinetics of the small molecule therapy HDM1002

You may see greater results or faster results if you also add glycolic acid to the treatment

Obici recommends consuming 60 to 75 grams of protein a day to preserve lean mass during weight loss