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Higher doses also tended to be harder to tolerate
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GLP-1 medications are protein-based biologics susceptible to degradation from temperature extremes, requiring refrigeration between 2C and 8C before opening
Interestingly, excessive ROS production and oxidative stress raises the binding affinity of the spike protein for the human ACE2 receptor (Hati and Bhattacharyya, 2020
The study also focused only on semaglutide, and the findings cannot be immediately generalized to other GLP-1 drugs
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