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One of the most effective tools she uses is the GLP-1 class of medications, along with other approved weight loss medications
Thymidylate synthase (TYMS) converts deoxyuridine monophosphate (dUMP) and 5,10-methyleneTHF to deoxythymine monophosphate (dTMP) and dihydrofolate (DHF) in the de novo synthesis of pyrimidines
These studies, found mostly in mice, have shown insoluble fiber may contribute to weight loss because the speed in which food is digested increases, and therefore, we dont absorb as many calories
GLP-1RAs are synthetic molecules that mimic the effects of the naturally-occurring GLP-1 hormone, including increasing insulin secretion and slowing gastric emptying
Most people in maintenance need to eat at or slightly above their new TDEE to prevent further weight loss while deciding how long to continue semaglutide
![Efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1](https://www.researchgate.net/publication/363201315/figure/fig3/AS:11431281082605778@1662084799021/Efficacy-of-tirzepatide-in-phase-2-GPGB-14-and-phase-3-SURPASS-1-to-5-15-19.png)
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