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The foremost limitation is the absence of large-scale, randomized, and well-controlled clinical trials capable of establishing definitive evidence of safety and efficacy in human populations
Foundational Phase 1: Safety & Pharmacokinetics The most critical formal study remains the PharmaCotherapia d.o.o
Experimental literature has also investigated VEGF and VEGFR2 signaling, growth hormone receptor expression in tendon fibroblasts, neurotransmitter modulation, and neuroprotective pathways involving the dopaminergic and serotonergic systems
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