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This increased nitrosative and oxidative stress results in activation of poly(ADP-ribose) polymerase-1 (PARP-1) to prevent DNA damage [366]
Moreover, treatment with mitochondria-targeted antioxidant MitoQ preserves mitochondrial quality control, alleviates tubular injury, and restores kidney function by reversing mitophagy deficiency through the Nrf2/PTEN-induced kinase 1 (PINK) signaling pathway in db/db mice (68)
S -conjugates, and glutathione complexes)
a ROS, reactive oxygen species
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