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Tirzepatide 15 mg produced 5.5 kg more weight loss than semaglutide 1 mg (p 25,000 participants in the SURPASS and SURMOUNT programs [1, 2, 3]: Gastrointestinal effects (most common, dose-dependent): Nausea: 12-18% (5 mg), 15-22% (10 mg), 18-28% (15 mg) vs
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SGLT2i versus DPP4i initiation was associated with a 14% lower dementia risk in the intention-to-treat analysis (HR 0.86, 95% CI 0.790.94
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