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Human files were searched against the UniProtKB/Swiss-Prot protein database (release date: 07/18/2018, including common protein contaminations) by ProteinPilot 5.0 software (Sciex) using the Paragon Algorithm (Shilov et al., 2007)

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We also highlight potential issues and challenges encountered in practical applications, including the determination of multi-factorial weightings, requirements for data quality and quantity, establishment of unified predictive indicators and standards, enhancement of model generalizability, and interpretability of prediction outcomes

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Amyotrophic Lateral Sclerosis and pain: a narrative review from pain assessment to therapy