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Materials and methods Experimental animals The animal experiments were performed on the basis of ethical regulations for animal testing, and the animal protocol employed in this study was approved by the Animal Experimentation Committee of Jinan University (IACUC-20191212-02)

Qin et al

ATP is produced by the mitochondria via aerobic metabolism, meaning oxygen must be present

Accessed: Apr

5 The role of iron in CNS resident cells As the relationship between iron and glial cells were already covered in previous reviews (4648) [see the previous references for a detailed review on the subject], in this section, we briefly mention the role of iron in different CNS resident cell types that are relevant to MS pathophysiology and highlight the contribution of the iron dyshomeotasis in these cells as an underpinning mechanism of disease progression