NNMT is over-expressed in fat and liver tissue in obese, diabetic animals, and genetic knockdown of NNMT protects mice against diet-induced obesity by increasing energy expenditure
By inhibiting NF-kB activation, it could potentially reduce the inflammatory cascade that drives flare severity without compromising the immune response to concurrent infections, a common concern during lupus flares when patients may also be on immunosuppressive medications
K.MoselerA.SchwarzlnderM.et al (2019)
It supports blood vessel formation, enhances nitric oxide production, and encourages the repair of tissues like muscles, tendons, ligaments, and the stomach lining
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