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User experimentation suggests that longer initial treatment periods (6+ months continuous) support better benefit retention during subsequent breaks, complete discontinuation breaks of 1-2 months show acceptable benefit maintenance for most users, and very extended breaks (3-6+ months) increase risk of regression toward pre-treatment baseline particularly for short initial treatment courses

Jan 2013;405(2-3):585-601

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Because they operate through distinct pathways, GHK-Cu and AHK-Cu are complementary rather than redundant

Simplified stacks Not everyone needs a comprehensive four-peptide stack