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So patients will be eligible for the bridge if they have a BMI of 35 or higher, a BMI of 30 or higher with uncontrolled hypertension, chronic kidney disease stage 3A or above, or heart failure with preserved ejection fraction

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According to FDA labeling and clinical guidelines, semaglutide should be used with a reduced-calorie diet and increased physical activity

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Manganese-potentiated cGAS-STING activation with ATM/PRMT5 inhibition remodels the immunosuppressive microenvironment in osteosarcoma via bone-targeted delivery