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One of the first clinical studies done on DSIP demonstrated that the peptide was exceptionally well tolerated
For example, emerging protein targets like IL-4, IL-10, IL-15, IL-17, IL-18, IL-23, interleukin-1 receptor-associated kinase (IRAK)-4 have been revealed to have a strong implication with innate and adaptive immune response in RA ( Protein Targets for Treatment of Rheumatoid Arthritis Currently, many agents aiming at various protein targets have been explored and tested to ease the progression of RA, and some agents have been used in the clinic to treat RA patients ( Table 1 )
This adverse effect has not yet been clinically reported Hypopigmented patches, especially on sun-exposed areas have been observed after 1012 doses of intravenous injection by practitioners (unpublished observations)
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