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Cellular capacities for ROS elimination are limited in Nrf2 -null mice ( Nrf2 -null mice tend to spontaneously develop various inflammatory disorders, including glomerulonephritis, immune-mediated hemolytic anemia, and multi-organ autoimmune inflammation (Yoh et al., 2001
& Te Morenga, L
& Turley, E
Dosage Guidelines Following the correct dose is crucial for effectiveness
Body mass increased only 30% in old Has1,3 dko mice and was less than old WT mice
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