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Proteostasis decline may also contribute to oocyte aging through impaired protein folding, aggregation, and reduced activity of the ubiquitinproteasome and autophagy systems

Indeed, GSH, Trx, Grx, Prx (together with the enzymes catalyzing their reduction), and the enzymatic antioxidant defense, as a whole, concur to modulate either ROS concentration, or the availability of cellular thiols, thus regulating the function of a large number of proteins implicated in the induction and/or execution of redox-sensitive pathways

Int J Med Mushrooms 19(2):179189 Zheng H, Kim J, Liew M, Yan JK, Herrera O, Bok JW, Kelleher NL, Keller NP, Wang Y (2015) Redox metabolites signal polymicrobial biofilm development via the NapA oxidative stress cascade in Aspergillus

Activation of rodent adipocyte beta-3 receptors can promote cAMP signaling, stimulated lipolysis, and thermogenic responses

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