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Transcriptional up-regulation of gamma-glutamylcysteine synthetase gene expression in melphalan-resistant human prostate carcinoma cells
References Richie JP Jr, Leutzinger Y, Parthasarathy S, Malloy V, Orentreich N, Zimmerman JA
Unchecked free radicals continuously damage cellular lipids and proteins, triggering a vicious cycle of systemic inflammation
PARP-1 contributes significantly by selectively binding to cisplatin-induced DNA damage, particularly 1, 2-d(GpG) crosslinks ( Table 4 )
Additionally, there is an increase in circulating chemoattractant molecules, like monocyte chemoattractant protein (MCP)-1 and IL-8 (Close et al., 2013)
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