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Less frequently, some people might experience temporary fatigue, dizziness, or nausea
Phase 3 trials will provide a clearer side-effect picture
Occasionally, users report headaches or dizziness, particularly during initial use
PubMed Central (PMC)
Second, structural biology: cryo-EM structures of full-length MC4R in complex with heterotrimeric Gs, published in Cell Research in 2021, resolved bremelanotide in the orthosteric site alongside alpha-MSH, afamelanotide and a small-molecule agonist, establishing a conserved binding mode for the peptidic ligands and a distinct activation mechanism for MC4R
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