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When folate cycling is impaired by MTHFR insufficiency, the dihydrofolate THF step accumulates dihydrofolate, competing with the BH2 BH4 reduction step for DHFR activity and NADPH
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doi: 10.1016/j.cellsig.2024.111064 184 WeiXAdakSZayedMYinLFengCSpeckSLet al
This limits the generalizability of the findings to humans
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