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Transcriptomic analysis revealed significant differences in small intestinal GLP-1-secreting L-cells from GF versus conventional mice, including increased GLP-1 content in GF mice, which was rapidly altered following conventionalization, implicating a strong role of the gut microbiota in regulating EEC physiology 243

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Research models have examined its roles in: angiogenic signaling inflammatory modulation gastrointestinal mucosal protection connective-tissue and ligament studies neural protection models Most findings come from rodent studies and in vitro experiments, where researchers evaluate tissue-specific responses under controlled conditions