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What This Means for Our Practice Seven additional Phase 3 trials are expected in 2026, evaluating retatrutide across obesity, type 2 diabetes, sleep apnea, chronic low back pain, and MASLD

Appetite Regulation Semaglutide affects GLP-1 receptors in the gut and brain, which may reduce hunger signals and influence food cravings

A 2011 study of elite athletes losing weight at different rates found that those losing weight slowly (around 0.7% of body weight a week) gained 2.1% lean mass over the study

But it is still being studied

however, treatment discontinuation and patient adherence are still expected to remain important real-world challenges