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Consistently, our T-maze test also exhibited significant improvement in the performance of 5XFAD, as shown by increase in the number of positive turns (Figure 6F) and reduction of errors (Figure 6G), whereas 5XFAD Ppar-null mice and 5XFAD Ppar-Hippo mice did not display any improvement in T maze analyses (Figure 6, F and G), following Hex treatment, indicating a pivotal role of hippocampal PPAR in Hex-mediated improvement in spatial and contextual in 5XFAD mice