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Clinicians should consult primary FDA materials and counsel before changing practice

Upon undertaking further investigations to determine the factors mediating these changes, the investigators found that baseline white adipose tissue IL-1beta secretion accounted for much of the association between apoB and several diabetes-related traits, and these links were lost after omega-3 supplementation

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174 Similarly, endogenous microRNAs (e.g., miR-451 and miR-326) have been shown to negatively regulate MDR1 expression and restore drug sensitivity in breast and gastric cancers

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