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Treated wounds show tightly organized mature collagen fibers with reduced myofibroblast formation[10]
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However, naltrexone, as an opioid antagonist, may increase GABAergic interneuron activity, thereby enhancing GABAergic tone, which could lead to reduced glutamate release from pyramidal neurons and a consequent attenuation of ketamines acute excitatory effects
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The conversion of ribonucleotides to deoxyribonucleotides (through the action of ribonucleotide reductase) requires NADPH as the electron source, therefore, any rapidly proliferating cell needs large quantities of NADPH
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