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Before opening a cold vial, allow it to warm to room temperature to help prevent condensation from forming inside the vial
Dehydration can increase histamine levels and worsen allergy symptoms
Patients with insufficient glutathione stores (e.g., alcoholics and acquired immunodeficiency syndrome patients) and patients with induced cytochrome P-450 enzymatic activity (e.g., alcoholics and those taking concurrent anticonvulsant or antituberculous medications) may be at greater risk for developing acetaminophen-induced hepatotoxicity following overdose (as opposed to therapeutic dosing described earlier)
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