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Exenatide treatment for 12 months was generally well-tolerated in individuals with mild PD, which was defined as Hoen and Yahr (H&Y) stages 2 to 2.5
If you experience any concerning side effects, contact your healthcare provider immediately
Ibuprofen is available over the counter or with a prescription
Standard 4-Step Escalation Schedule | Week Range | Dose | Clinical Decision Point | |---|---|---| | Weeks 1 to 4 | 2 mg SC once weekly | Assess nausea, vomiting, GI tolerability | | Weeks 5 to 8 | 4 mg SC once weekly | Hold if nausea grade 2 persists | | Weeks 9 to 12 | 8 mg SC once weekly | Check fasting glucose, LFTs at week 12 | | Weeks 13 to 24 | 12 mg SC once weekly (target) | Confirm tolerability before locking dose | Patients who cannot tolerate the step-up to 8 mg may remain at 4 mg for an additional 4 weeks before retrying escalation
Everything else, the mechanism, the dosing, the clinical data, is academic unless you can translate it into practical strategies that protect your muscle while retatrutide does its work on your fat stores
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