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NAC modifies two key neurotransmitters glutamate and dopamine
For observational studies reporting serum vitamin B12 levels, the certainty of evidence was upgraded from low to moderate due to the large and consistent magnitude of effect across studies, despite heterogeneity
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One hypothesis is that C677Ts reduction in MTHFR activity is likely due to the fact that the alanine to valine amino acid change makes the enzyme more heat-sensitive
As a member of the aquaporins, aquaporin 4 (AQP4) is abundant in astrocytes processes and responsible for brain edema (Tang and Yang, 2016)
