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Earlier this month (June 2025), Novo Nordisk reported that it will advance to Phase III trials both subcutaneous and oral amycretin in weight management based on completed clinical studies

Some secretagogue receptors show measurable downregulation with repeated high-frequency dosing in research models, and comparing that pattern between Ipamorelin and other GHS-R1a ligands is a common design element in longer observation studies

On the flip side, the drugs can cause gastrointestinal problems including diarrhea, constipation, nausea and vomiting