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And calorie restriction in non-obese populations can improve metabolic health by reducing energy intake (e.g., 25%), manifesting as weight loss, enhanced insulin sensitivity, decreased cardiovascular risk factors (such as blood lipids and blood pressure), and activation of aging-related molecular pathways (e.g., enhanced mitochondrial function and DNA repair) [19]
Kaplanski G, Marin V, Montero-Julian F, Mantovani A, Farnarier C
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