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The downstream effects include activation of hormone-sensitive lipase in adipose tissue (which breaks down stored triglycerides into free fatty acids), increased protein synthesis in skeletal muscle, enhanced cellular repair and turnover, elevated IGF-1 production from the liver, and improved lipid metabolism including reduced triglycerides
By blocking both type I and type II 5-alpha reductase enzymes (compared to finasteride which only blocks type II), dutasteride provides more complete androgen suppression at the follicle level
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Not FDA-approved or available by prescription
Acknowledgments SS acknowledges the receipt of the fellowship from UGC, New Delhi
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