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Acknowledgments The authors gratefully acknowledge the Board of the Instituto da Criana, Hospital das Clnicas, for their institutional support, with special thanks to Dr

However, when combined with insulin or sulfonylureas, the risk increases significantly, and dose adjustments of these medications may be necessary

Apoptosis can be initiated via two major pathways: the intrinsic (mitochondria-dependent) pathway, which is triggered by cellular stress and mitochondrial outer membrane permeabilization, and the extrinsic (death receptor-mediated) pathway, both of which converge on the activation of caspases to execute cell death [53]

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In this respect, the N-glycosylation pathway (Filippo et al., 2011), as well as a more complicated process involving a multiprotein complex that traffics OCTN2 to the definitive location, have been described (Jurkiewicz et al., 2017)