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Previous work has shown that the abundance of Lactobacillus reuteri (normalized to a control group) decreases during the onset of obesity and remains suppressed even after dieting in mice 99 , which parallels our observations that vehicle-treated diet-switched mice had lower levels of Lactobacillus than the 5A-1MQ-treated mice, the latter of which also demonstrated greater weight loss

According to the 2025 meta-analysis by Alfalasi and colleagues, sublingual B12 showed an approximate 199% mean increase in serum B12 compared to approximately 307% for intramuscular injections

The average weight loss was approximately 15% of body weight, with many participants achieving even greater reductions

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