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However, the 2012 Kidney Disease: Improving Global Outcomes guidelines state that metformin use should be continued in patients with an estimated glomerular filtration rate (GFR) of 45 mL per minute per 1.73 m 2 or greater
current evidence indicates that GLP-1 R expression is found predominantly within the ganglion cell layer (GCL), exclusively detected in a discrete subpopulation of neurons [37]
Blaylock RL, Maroon J
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