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Additionally, IR has been shown to induce the expression of genes that promote iron uptake while inhibiting genes that encode for iron storage or export [38, 44]

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Beyond its primary function, iron is required also for thyroid hormone synthesis because the thyroperoxidase enzyme (TPO) needs to bind with a heme group to become active on the apical membrane of thyroid cells

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A double-blind, placebo-controlled study published in the Journal of Pakistan Association of Dermatologists found that 1,200 mg of intravenous glutathione administered twice weekly for six weeks produced visible skin tone lightening in 37.5% of participants