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The peptide is naturally occurring and well-tolerated
Because of its abundance, GSH plays a key role in maintaining cellular redox homeostasis and in cellular mechanisms that protect against oxidative stress
However, the optimal level of glutathione (GSH) is easily compromised
Cisplatin accumulates persistently in the mitochondria of energy metabolism-related organs (skeletal muscle, liver), forms platinum-mtDNA adducts to disrupt mitochondrial structure and function, and causes oxidative phosphorylation impairment and insufficient ATP production, ultimately driving persistent fatigue (Huot et al
Dec 21 2017
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