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Consider earlier administration (3+ hours before bed) to allow cortisol-modulating effects to establish before sleep pressure builds

This is why self-directed dosing is risky and why provider-guided treatment is the safer route

On the other hand, protective bacterial species, such as Bifidobacterium, Lactobacillus and Butyricicoccus, that promote a healthy gut barrier and enhance immune tolerance, are reduced in patients with HT [182]

It is caused by the caloric restriction and rapid weight loss, which trigger a shift of hair follicles from the growth phase to the resting and shedding phase