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Kuznetsova NR, Sevrin C, Lespineux D et al (2012) Hemocompatibility of liposomes loaded with lipophilic prodrugs of methotrexate and melphalan in the lipid bilayer
These were further chelated by Mn ions for serving as a magnetic resonance imaging (MRI) contrast agent and PEGylated (HMONs-MnPpIX-PEG) [66]
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These effects typically peak during dose escalation periods and often diminish with continued use as physiological adaptation occurs
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