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Intriguingly, one of these studies also showed that longer administrations can lead to a normalization of anxiety and a dissociable improvement in depression-like behavior 158 a pattern that resembles of the mechanisms of action of conventional antidepressants and that may be further suggestive of the activity of GLP-1RAs on the serotonin system 158

During our previous characterization of molecular pathways leading to wheat resistance to Hessian fly using microarrays, we have found that the transcript levels of a large number of genes encoding various enzymes involved in glutathione metabolism are strongly affected in resistant plants after Hessian fly attack 21,27 , indicating that glutathione may play an important role in wheat defense against Hessian fly attack