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We demonstrated that, at low doses (ng), local (intraplantar) or systemic (intraperitoneal) injections of thymulin resulted in hyperalgesia with an increase in proinflammatory mediators, and that this peptide could act directly on the afferent nerve terminals through prostaglandinE2 (PGE2)dependent mechanisms, thus forming a neuroimmune loop involving capsaicinsensitive primary afferent fibers
Topical application is the most common and well-studied route, particularly for skin and wound healing research
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In some cases, hyaluronic acid is also included to hydrate and plump the skin
Peripheral and mesencephalic transfer of a synthetic gene for the thymic peptide thymulin Type of study: non-rct experimental Number of citations: 8 Year: 2006 Authors: G
