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In endothelial cells, the accumulation of HIF-1 results in the upregulation of VEGF, consequently increasing vascular permeability, compromising the integrity of the blood-brain barrier, and inducing vasogenic cerebral edemaIn microglia, HIF activation of the NF-B signaling pathway facilitates the release of proinflammatory cytokines, such as IL-6, IL-1, and TNF-, increases vascular permeability, and contributes to cerebral edema

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M.CarrilhoE.et al