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Wegovy is not recommended in patients with severe gastroparesis
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The safest protocol is dosing 12 hours before drinking begins and again after drinking stops, allowing hepatic stores to be maximised when acetaldehyde accumulation is highest
1 2 Valproate FDA Professional Drug Information
Side effects are broadly similar, with tirzepatide more often linked to nausea and vomiting, and semaglutide more to constipation and reflux
In the SUMMIT trial, tirzepatide reduced the combined risk of cardiovascular death or worsening HF, and improved health status and exercise tolerance in patients with obesity-related HFpEF 16
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