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waf1/cip1 , proapoptotic protein Bax-1 and cleaved caspase 3 but also reversed the increase in the cell proliferation markers including cyclin D1 and PCNA, suggesting that lycopene protects the gastric mucosa from smoking-induced damage through p53-dependent cell cycle control and apoptosis, and may counteract the development of gastric cancer associated with smoking (Liu et al., 2006) (Figure 3)

PANoptosis-related gene signatures are strongly enriched in the renal tubulointerstitial tissue of patients with DKD, serving as a comprehensive indicator of tubulointerstitial injury (209211)