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The inclusion criteria were (1) research/review articles on sources and generation of reactive free radicals, (2) research/review articles with experimental data on ROS-associated diseases, (3) research/review articles with experimental data on antioxidant activity, (4) research/review articles exploring the mode of action of synthetic as well as natural antioxidants
10.2174/2211536611666220922092601 3 AdinewG
Skeletal muscle wasting Loss of skeletal muscle mass is associated with a decrease in muscle strength and occurs with aging (119), as well as in several pathological conditions (120-122)
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For example, C16-carnitine (10 M) may impair mitochondrial function in rat ventricular myocytes by accelerating ROS production and increasing the probability of mitochondrial permeability transition pore (mPTP) opening, whereas low concentrations (1 and 5 M) of C16-carnitine lightly hyperpolarize the m but do not open the mPTP [293]
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