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10.1016/j.clinre.2022.101922 58 RenQ.ChenS.ChenX.NiuS.YueL.PanX.et al (2022)

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GLP-1 medications are being studied for an expanding range of conditions including autoimmune conditions , cardiovascular risk reduction, non-alcoholic fatty liver disease, and neurodegenerative diseases

The improved functioning of the BBB, enhanced clearance of metabolites and protein fragments implicated in AD from the brain - an astrocyte-dependent mechanism primarily occurring during sleep [14] - and enhanced insulin signaling, suggested to play a role in AD [33], present additional mechanisms by which melatonin may impact AD pathology