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A randomized placebo-controlled trial that included 1,312 individuals with type 2 diabetes demonstrated that 1 gram of EPA and DHA, plus 50 mcg (2,000 IU) of vitamin D, taken daily for five years had no effect on the progressive loss of kidney function

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While animal models and in vitro cultures provided the "proof of concept," the 2026 reclassification has allowed for the validation of these mechanisms in human clinical settings

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