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To meet the diagnostic criteria for cvEDS, a person must meet: Major criterion 1 AND family history compatible with autosomal recessive inheritance AND at least one other major criterion OR Major criterion 1 AND family history compatible with autosomal recessive inheritance AND at least two minor criteria Major Criteria Severe progressive cardiac-valvular problems (aortic valve, mitral valve) Skin involvement: skin hyperextensibility, atrophic scars, thin skin, easy bruising Joint hypermobility (generalized or restricted to small joints) Minor criteria Inguinal hernia Pectus deformity (especially excavatum) Joint dislocations Foot deformities: pes planus, pes planovalgus, hallux valgus Classical-like EDS (clEDS) If a person meets the diagnostic criteria for clEDS, genetic testing should be done to confirm the diagnosis

The most common players in the lab are: Dimethyl sulfoxide (DMSO) Dimethylformamide (DMF) Acetonitrile (ACN) The trick here is to be strategic

To further groups of five anaesthetized rats, different doses of the peptides formulated in the Axcess vehicle comprising a mixture of 50 mg sodium chenodeoxycholate and propyl gallate (2:1 wt:wt) were dissolved in water and instilled by injection directly into the intestinal lumen of the anaesthetised rats using an insulin syringe with a 30 gauge needle (t = 0 min)

Alam M, Ahmed M, Altaf M, Shaik JP