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In comparison, people with good tolerance who do not experience severe side effects can escalate their doses according to the standard prescribing schedule
The STEP-1 trial (N=1,961) documented nausea in 44.2% of semaglutide 2.4 mg participants versus 16.0% of placebo participants at any point during the 68-week study [2]
The injectable formulations are administered once weekly via subcutaneous injection, meaning the medication is delivered into the fatty tissue layer beneath the skin rather than into muscle or directly into the bloodstream
Gradual dose titration, smaller meals, avoiding high-fat foods, and staying upright after eating can reduce nausea and vomiting