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The standard evaluative statement is this: preclinical evidence across multiple rodent models is consistently favorable

So to this question of whether its the weight loss or the drugs, the answer is probably both are important. For Verma, getting to the exact mechanism of benefit is more of an academic exercise because at the end of the day, for the patient in the trenches who is really suffering with heart failure with preserved ejection faction in the context of obesity-related heart failure and is limited with symptoms and physician function, the mechanism of benefit is less relevant to them as long as it is leading to an improvement in clinical signs and symptoms. Increasing Adoption Despite the positive results of trials of semaglutide and other GLP-1 receptor agonists indicating benefits beyond just weight loss, patients are still finding it difficult to access the drugs