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Gastrointestinal adverse events including nausea, vomiting, and diarrhea are common with current GLP-1 agonists, leading some patients to discontinue treatment or fail to reach maximally effective doses
Drinking plenty of water will help
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They advise thorough evaluation for any history of pancreatitis, and careful monitoring for gastrointestinal side effects, which, while usually transient, can be a barrier to adherence
