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They may also be helpful for people whose diets have changed significantly, especially if they are eating fewer animal-based foods or following a reduced-calorie plan that limits certain nutrients

Both ACOG and the Endocrine Society recommend FDA-approved formulations as the starting point for menopausal hormone therapy

Standard escalation follows: 0.25mg weeks 1-4, 0.5mg weeks 5-8, 1.0mg weeks 9-12, with potential further increases to 1.7mg or 2.4mg based on response

This direct contact may enhance local tissue effects beyond what systemic administration achieves

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